10 Years of Intractable Diarrhea

A recent report (JPGN 2014; 59: 571-76) from Turkey reviewed their experience with intractable diarrhea of infancy from 2000-2010.  This retrospective review included 60 hospitalized patients.

Key findings:

  • Carbohydrate malabsorption, including glucose-galactose malabsorption, and food allergy accounted for 11 patients (18%) each.
  • 16 patients (27%) had no definitive diagnosis.
  • Other etiologies included infections, inflammatory bowel disease, autoimmune enteropathy, microvillus inclusion disease, tufting enteropathy, short bowel syndrome, cystic fibrosis, proprotein convertase 1 deficiency, congenital disorder of glycosylation, abetalipoproteinemia.

The authors provide a useful diagnostic algorithm (Figure 1).

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2 thoughts on “10 Years of Intractable Diarrhea

  1. Pingback: Another Rare Cause of Neonatal Diarrhea | gutsandgrowth

  2. Pingback: If I ever see an infant with Congenital Sodium Diarrhea | gutsandgrowth

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