Previously, this blog noted that a phase II study showed that Mongerson, an oral SMAD7 antisense oligonucleotide, had promising data for moderate-to-severe Crohn’s: An Oral Oligonucleotide in the Crohn’s Treatment Pipeline …
The study has now been been published: NEJM 2015; 372: 1104-13. Among patients who received 40 mg and 160 mg of mongerson, remission (CDAI <150) at 15 days was achieved in 55% and 65% respectively compared to 12% for 10 mg dose and 10% for placebo group.
The associated editorial (pg 1166-67) notes that only 18% of the patients with elevated C-reactive protein and randomized to the 40 mg and 160 mg doses normalized these levels at the end of the treatment period. Thus, further trials will need to look more closely at objective biomarkers.
Unrelated but interesting -from John Pohl & Bryan Vartabedian’s twitter feeds: “Food Babe” Exposed as a Fraud