A clinical pearl is “a short, straightforward piece of clinical advice.” Here are a few:
2015 DDW abstract –#536 DR Hoekman et al “Non-trough IFX concentrations reliably predict trough levels and accelerate dose-adjustment in Crohn’s disease.” This abstract examined data from 20 CD patients. The authors noted that infliximab concentrations of 15 mcg/mL or higher at week 4 and 7.5 mcg/mL or higher at week 6 appeared to predict trough concentrations of 3 mcg/mL or higher at week 8.
U Kopylov et al. Inflamm Bowel Dis 2015; 21: 1847-53. This nested case control study identified 19,582 eligible patients. Key findings:
- Treatment with thiopurines for more than 5 years did not increase the risk of lymphoma, melanoma or colorectal cancer.
- There was an association between thiopurine use and nonmelanoma skin cancer (OR 1.78).
- No association was found between the risk of the evaluated malignancies and anti-TNFα medications
K Huth et al. Inflamm Bowel Dis 2015; 21: 1761-68. This prospective cohort study completed over 2 successive influenza seasons showed that offering education and access to vaccination improved rates of vaccination from 47% (2011-12) to 75% (2013-14). The education module is available: www.cheo.on.ca/en/IBDflu
KH Katsanos et al. “Review article: non-malignant oral manifestations in inflammatory bowel disease” Aliment Pharmacol There 2015; 42: 40-60. (Thanks to Ben Gold for this reference). This review article provides extensive information about oral lesions in IBD, differential diagnosis, numerous pictures, and management recommendations. Some oral lesions are directly related to IBD, others can be induced by vitamin deficiencies or by medications.
Disclaimer: These blog posts are for educational purposes only. Specific dosing of medications/diets (along with potential adverse effects) should be confirmed by prescribing physician/nutritionist. This content is not a substitute for medical advice, diagnosis or treatment provided by a qualified healthcare provider. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a condition.