AGA Guidelines on Diagnosis and Management of Lynch Syndrome: JH Rubenstein et al. Gastroenterol 2015; 149: 777-82. Technical Review 783-813. Patient Guideline Summary 814-14.
MB Yurgelun et al. Gastroenterol 2015; 149: 604-13. Multigene panel testing from 1260 individuals with clinical Lynch syndrome. 9% had Lynch syndrome mutations identified, 5.6% had other cancer predisposing genes (eg. BRCA1) identified, and 479 had variants of uncertain clinical significance.
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