A recent systematic review/meta-analysis (MI Pinto-Sanchez et al. J Pediatr 2016; 168: 132-43) identified 15 eligible studies among an initial search of 1982 studies.
- There was a 25% increase in celiac disease risk with late (>6 months) vs recommended (4-6 months) gluten introduction.
- There was no significant effect of breastfeeding or not breastfeeding.
The authors state there is no evidence on whether early introduction (<4 months) of gluten would affect the risk of celiac disease. Late introduction (>6 months) is associated with increase risk of celiac disease.
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