G Parthasarathy et al. Gastroenterol 2016; 150: 367-79. Mucosal and fecal microbiota samples were collected from 25 healthy women and 25 women with chronic constipation. Key finding: The mucosal, but not fecal, microbiota profile were 94% predictive of constipation. The associated editorial (pg 300) provides a framework for understanding these findings and show the complexity of trying understand the interations between diet, motility and microbes.
S Fukudo et al. Gastroenterol 2016; 150: 358-66. This prospective study of Ramosetron for 576 women with IBS-D. Key finding: 50.7% of treatment patients reported global improvement compared with 32.0% of control patients. Patients had less abdominal pain, less discomfort, and better stool consistency. Ramosetron, a 5-HT3 antagonist, has not been reported to cause ischemic colitis (in contrast to alosetron).
In followup to a post earlier in the week, another worrisome study on the Zika virus in pregnancy from NEJM. Here’s an excerpt:
Fetal abnormalities were detected by Doppler ultrasonography in 12 of the 42 ZIKV-positive women (29%) and in none of the 16 ZIKV-negative women. Adverse findings included fetal deaths at 36 and 38 weeks of gestation (2 fetuses), in utero growth restriction with or without microcephaly (5 fetuses), ventricular calcifications or other central nervous system (CNS) lesions (7 fetuses), and abnormal amniotic fluid volume or cerebral or umbilical artery flow (7 fetuses).