CCFA Conference Notes 2016 (part 5) -Emerging Therapies

This blog entry has abbreviated/summarized this terrific presentation; most of the material has been covered in this blog in prior entries (can use search function to find additional relevant material) but still this was a useful review. Though not intentional, some important material is likely to have been omitted; in addition, transcription errors are possible as well.

Emerging Therapies in IBD –Dr. Gary Lichtenstein

Background: This lecture started with a review of current therapies. We have learned how to use our current therapies better. There still remain a large number of patients that face surgery with IBD; though there has been improvement (?50% reduction).

Issues with thiopurines were reviewed. May take 2-6 months to take effect, though monotherapy with thiopurines are fairly ineffective for Crohn’s disease as initial therapy.

Leukocyte Trafficking Agents:

  • Natalizumab
  • Vedolizumab
  • AJM300 –oral agent. Initial safety data were fine.
  • AMG 181
  • Etrolizumab (Vermeire S Lancet 2014) –low rates of endoscopic healing, but better than placebo

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PF-00547,659

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S1P Modulators:

Fingolimod

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Ozanimod (RPC1063) (oral agent, fairly rapid onset) causes S1P-r on lymphocytes to be internalized –more selective than Fingolimod. Good safety has been noted thus far.  No notable cardiac problems. Infrequent elevations of transaminases; this issue will need to be followed.

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Tofacitinib oral Janus Kinus (JAK) Inhibitor (Sanborn WJ et al. NEJM 2012; 367: 616-24). Dr. Lichtenstein thinks 10 mg will be recommended dose. Follow lipids. For UC

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Mongerson related post: Mongerson -Phase II Data Available in NEJM | gutsandgrowth

 

Ustekinumab

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Related article from GI & Hep News: Ustekinumab for complex Crohn’s from ECCO conference/UNITI-1 Study (n=741)

FMT.  Further studies are needed

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One thought on “CCFA Conference Notes 2016 (part 5) -Emerging Therapies

  1. Pingback: More on Ustekinumab, plus Allopurinol Study | gutsandgrowth

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