Another large study (Kabbani TA, et al. Am J Gastroenterol. 2016;doi:10.1038/ajg.2016.53) links low vitamin D status with worse outcomes in IBD.
An excerpt from summary from HealioGastro: (Low vitamin D linked to higher morbidity, disease severity in IBD)
Binion and colleagues identified 965 IBD patients (61.9% Crohn’s disease; 38.1% ulcerative colitis; 52.3% women; mean age, 44 years) with up to 5 years of follow-up data in University of Pittsburgh Medical Center’s longitudinal IBD natural history registry…
At enrollment, 8.9% of patients were vitamin D deficient and 33.1% had vitamin D insufficiency vs. 4.9% and 23.6%, respectively, at the conclusion of the study period. Among patients who received vitamin D supplements, 67.9% achieved normal levels by the end of the study…
Overall, patients with low vitamin D levels required significantly more steroids, biologics, narcotics, computed tomography scans, emergency department visits, hospital admissions and surgeries compared with those who had normal mean vitamin D levels (P < .05). They also had worse pain, disease activity scores and quality of life (P < .05).
“More importantly, correction of vitamin D deficiency was associated with overall improvement in clinical status,” Binion said.
My take: Vitamin D levels are often low when patients are acutely ill and can improve without supplements in many; this accounts for some of the association with worsened outcomes. True vitamin D deficiency and insufficiency does have negative physiologic effects and should be treated.
Related blog posts:
- Another Reason for Inflammatory Bowel Disease Patients to …take Vitamin D
- Single High-Dose Oral Vitamin D Therapy … – gutsandgrowth
- Explaining the Vitamin D Paradox | gutsandgrowth
- Why Adding Vitamin D May Not Help IBD | gutsandgrowth
- The Search for a Dietary Culprit in IBD | gutsandgrowth
- Vitamin D, IBD, and Causality | gutsandgrowth
- Common to be “D-ficient” | gutsandgrowth