Chronic Granulomatous Disease and GI Involvement

Chronic granulomatous disease associated inflammatory bowel disease primarily involves the anus and rectum (SK Khangura et. al. Clin Gastroenterol Hepatol 2016; 14: 395-402).  In this study from the NIH, among 78 patients with CGD-IBD enteric fisula were found in 18% (73% were perianal), colonic stictures were noted in 24% (80% in anorectal area).

Other findings:

  • -EGD showed inflammation in 21%, 74%, and 37% of patients in esophageal, gastric and duodenal biopsies respectively
  • -Small bowel disease was unusual, though two of the four patients with ileostomies had ileal ulcers
  • -” ‘Target-like lesions,’ which have a clear elevated center with surrounding erythema, were characteristic of mild disease
  • -Approximately 40% of CGD patients have GI tract involvement
  • -GI tract malignancy was not observed in this cohort
  • -24 patients had pancolitis

My take: This reference provides comprehensive details of the clinical features of a large cohort with CGD.

Which animals kill the most humans

Which animals kill the most humans


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