A recent study (RE Kramer, MR Narkewicz. JPGN 2016; 62: 828-33) report the frequency of adverse events that occurred within 72 hours in a prospective observational cohort of 9577 patients from a single center.
The authors characterized complications more precisely and identified a much higher rate of complications than what has previously been reported. Key findings:
- The overall adverse event rate was 2.6% with 1.7% of all cases requiring unanticipated medical care.
- Absolute risk of bleeding was 0.11%, infection 0.07%, and perforation 0.1% (n=12). In total, these standard measures of complications were 0.28%.
- Advanced and therapeutic cases had much higher rates of adverse events. Perforations occurred after esophageal dilatation (5), esophageal food impaction (1), polypectomy (4), and primary GJ placement (2).
- Adverse rate with ERCP was 11.54%
- Adverse rate with PEG was 10.71%
- Adverse rate with dilatation was 10.94%. It is noted that a total of 319 dilatations were reviewed. 5 had perforations.
- Adverse rate with polypectomy was 6.27%. It is noted that a total of 128 polypectomies were reviewed. 4 had perforations.
- The authors did not identify a significantly higher complication rate with trainee physicians.
As noted in a previous entry (see below), studies in adults have an estimated a perforation rate of 0.09% and serious complication rates (GI and non-GI complications) of 0.15% for upper endoscopy and of 0.2% for colonoscopy. In addition, a large pediatric study of endoscopies, found a perforation rate of 0.014% for EGDs and 0.028% for colonoscopies. Thus, this report identifies a higher rate (10-fold) of perforation (driven by therapeutic endoscopy) and a much higher rate of adverse events, including 2.08% in diagnostic EGD and 3.9% for diagnostic colonoscopy. Furthermore, for diagnostic EGD and for diagnostic colonoscopy, grade 2 (needing ER or unanticipated physician evaluation) or higher adverse events occurred in 1.21% and 2.31% respectively.
My take: Using a broader (and more accurate) definition of complications after endoscopy, the authors have demonstrated a much higher rate of adverse events, particularly following dilatation, PEG, polypectomy, and ERCP. This report indicates that our preop counseling needs to be modified to inform families that complications are not quite so rare.
Related blog post: High Endoscopy Complication Rate After Intestinal …
Complication -Unrelated to endoscopy: