Using a matched cohort design with 1215 cases of celiac disease and 6075 controls, C Canova and colleagues (J Pediatric 2016; 174: 146-52) provide data from 1989-2011 regarding the development of hypothyroidism and diabetes. This retrospective, longitudinal, population-based Italian study relied on data from the integrated National Health Service.
- Over this >20 year period, the risk of developing hypothyroidism was HR 4.64 and the risk of developing type 1 diabetes mellitus was HR 2.50 (not statistically significant)
- The risk of hypothyroidism was more prevalent in males with HR 20.00.
The authors note: “The most plausible mechanism explaining the association between CD and T1DM/ATD [autoimmune thyroid disease] is a shared genetic background.”
Also noted: NASPGHAN Clinical Report on the Diagnosis and Treatment of Gluten-related Disorders. ID Hill et al. JPGN 2016; 63L 156-63. Recommended monitoring for celiac disease, from Table 5:
- At diagnosis: CD serology, CBC, Iron profile, HFP, Thyroid tests (TSH, free T4), Calcium, Vit D.
- At 3-6 mo after diagnosis: CD serology (TTG IgA or DGP-IgG)
- Annually: CD serology, CBC, Thyroid tests (TSH, free T4), Vit D.
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