IN 1862, Maurice Raynaud described a 26-year-old female patient: “Under the influence of a very moderate cold…she sees her fingers become ex-sanguine, completely insensible, and of a whitish-yellow color. This phenomenon …lasts a variable time, and terminates by a period of very painful reaction, during which the circulation is re-established…and recurs to the normal state.”
An updated review on Raynaud’s: FM Wigley, NA Flavahan. NEJM 2016; 375: 556-65.
This review highlights treatments and the differential diagnosis of primary Raynaud’s phenomenon form secondary causes (eg scleroderma, SLE, dermatomyositis, Sjogren’s and others).