- DR Hoekman et al. J Pediatr 2017; 182: 155-63.
- M Saps et al. J Pediatr 2017; 182: 150-54.
In the first study, Hoekman et al identified 21 studies to determine the placebo response in pediatric abdominal pain-related functional GI disorders. The authors found a pooled response to placebo of 41% (improvement) and resolution with placebo occurred in 17%.
The second study examined 289 children (55% U.S., 45% Italy) comparing the frequency of functional GI disorders in children with celiac disease on a gluten free diet compared with controls. Overall, chronic abdominal pain was present in 30.9% of subjects with celiac disease compared with 22.7% of sibling controls and 21.6% of unrelated controls. This did not reach statistical significance.
Related post: Is functional pain more common with celiac disease?